Table 1. Genes we related with psychiatric traits in the MR and colocalization analysis.

Wald ratio (WR) estimate with standard error (SE) and p-value, coloc (posterior probability of colocalization between gene expression and outcome). WR represents the genetically predicted log odds change in risk per standard deviation (SD) change in gene expression.

outcome	exposure gene	SNP	cytogenic	WR	SE	P	coloc
anorexia	SUOX	rs1081975	12q13.2	-0.366	0.072	3.00x10-7	93.4
bipolar disorder	RHEBL1	rs7969091	12q13.12	0.400	0.075	8.63x10-8	98.2
major depressive disorder	PTPN1	rs718050	20q13.13	-0.195	0.037	1.92x10-7	98.4
schizophrenia	FURIN	rs4702	15q26.1	-0.237	0.034	2.55x10-12	100.0
	ZNF823	rs72986630	19p13.2	0.238	0.044	4.90x10-8	100.0
	THOC7	rs832187	3p14.1	-0.163	0.029	2.57x10-8	99.3
	PTPRU	rs1498232	1p35.2	-0.256	0.042	1.22x10-9	99.0
	FAM85B	rs2980436	8p23.1	-0.126	0.023	7.47x10-8	98.9
	KCNQ5	rs2492966	6q13	0.241	0.045	1.05x10-7	98.6
	LINC00222	rs9398171	6q21	-0.253	0.046	3.05x10-8	98.6
	CLCN3	rs10520163	4q33	0.248	0.043	9.19x10-9	97.9
	RERE	rs2708630	1p36.23	0.193	0.034	1.54x10-8	96.7
	SF3B1	rs2564383	2q33.1	0.265	0.040	4.82x10-11	95.6
	FTCDNL1	rs281794	2q33.1	-0.167	0.023	7.75x10-13	95.2
	FAM86B3P	rs2945253	8p23.1	-0.075	0.015	3.54x10-7	94.5
	ZC3H7B	rs11090045	22q13.2	0.273	0.051	9.77x10-8	93.4
	INO80E	rs3814880	16p11.2	0.096	0.016	6.45x10-10	92.7
	GATAD2A	rs2905435	19p13.11	-0.137	0.025	4.11x10-8	92.4
	NAT8	rs10179134	2p13.1	0.145	0.028	2.16x10-7	91.4
	AC105749.1	rs11706780	3p22.2	-0.245	0.039	4.17x10-10	90.7
	PCCB	rs527888	3q22.3	-0.175	0.029	8.79x10-10	88.8
	AC243562.2	rs12905223	15q25.2	-0.113	0.018	4.82x10-10	87.5
	CNTN4	rs6796313	3p26.3	0.313	0.051	6.76x10-10	81.6
	NMB	rs56864281	15q25.3	0.307	0.051	1.38x10-9	78.8
	GOLGA2P7	rs2019611	15q25.2	0.110	0.019	2.64x10-9	75.2
	FES	rs6224	15q26.1	0.255	0.042	1.58x10-9	70.5