Table 3.
Cox Regression Analysis for All-Cause Death in All Patients and Those Aged ≥75 Years (A), and Stratified According to Treatment Era (B)
| (A) Variables | All patients (n=373) | Patients aged ≥75 years (n=276) | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age (every 10 years) | 1.75 | 1.53–2.00 | <0.0001 | 1.64 | 1.38–1.95 | <0.0001 |
| Male sex | 1.39 | 1.00–1.93 | 0.0484 | 1.32 | 0.93–1.87 | 0.1204 |
| Hypertension | 0.97 | 0.66–1.47 | 0.8942 | 0.99 | 0.65–1.56 | 0.9705 |
| Diabetes | 1.48 | 1.02–2.13 | 0.0386 | 1.54 | 1.02–2.31 | 0.0394 |
| Hypercholesterolemia | 0.53 | 0.35–0.79 | 0.0014 | 0.56 | 0.35–0.85 | 0.0066 |
| CAD | 0.88 | 0.59–1.27 | 0.5053 | 0.98 | 0.64–1.47 | 0.9267 |
| Stroke | 1.17 | 0.85–1.60 | 0.3387 | 1.22 | 0.87–1.72 | 0.2440 |
| Heart failure | 0.67 | 0.48–0.95 | 0.0232 | 0.62 | 0.43–0.91 | 0.0154 |
| PAD | 1.37 | 0.80–2.23 | 0.2333 | 1.22 | 0.69–2.04 | 0.4836 |
| Sustained AF | 1.27 | 0.88–1.86 | 0.2095 | 1.18 | 0.80–1.77 | 0.4224 |
| Oral anticoagulants | 0.62 | 0.44–0.88 | 0.0069 | 0.60 | 0.41–0.87 | 0.0074 |
| (B) Variable | Observations started | |||||
| Before 2009 (n=61) | In 2009 or later (n=328) | |||||
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age (every 10 years) | 1.15 | 1.07–1.25 | 0.0001 | 1.11 | 1.08–1.14 | <0.0001 |
| Male sex | 0.98 | 0.31–2.88 | 0.9750 | 1.56 | 1.09–2.23 | 0.0153 |
| Hypertension | 0.62 | 0.19–2.13 | 0.4345 | 1.03 | 0.68–1.62 | 0.8799 |
| Diabetes | 5.23 | 1.80–15.97 | 0.0025 | 1.18 | 0.78–1.75 | 0.4445 |
| Hypercholesterolemia | 0.72 | 0.21–2.14 | 0.5674 | 0.64 | 0.40–0.98 | 0.0395 |
| CAD | 1.68 | 0.63–4.22 | 0.2908 | 0.83 | 0.54–1.26 | 0.3881 |
| Stroke | 0.96 | 0.36–2.54 | 0.9264 | 1.18 | 0.84–1.65 | 0.3510 |
| Heart failure | 0.73 | 0.19–2.90 | 0.6430 | 0.63 | 0.44–0.90 | 0.0127 |
| PAD | 0.98 | 0.04–8.67 | 0.9866 | 1.34 | 0.78–2.20 | 0.2789 |
| Sustained AF | 5.70 | 1.40–30.58 | 0.0138 | 1.25 | 0.85–1.88 | 0.2642 |
| Oral anticoagulants | 0.48 | 0.17–1.45 | 0.1886 | 0.52 | 0.35–0.76 | 0.0008 |
Hazard ratios (HR) and 95% confidence intervals (CIs) are for the multivariate model, in which the covariables were forcibly included. AF, atrial fibrillation; CAD, coronary artery disease; PAD, peripheral artery disease.