Table 1.
Inhibitors used in drug assay.
| Drug | Mechanism of action | Published Cmax(μM) | Target concentration (μM) |
|---|---|---|---|
| Mocetinostat | HDAC inhibitor | 0.5 [39] | 0.5 |
| Trametinib | MEK1/2 inhibitor | 0.08 [40] | 0.1 |
| LY294002 | PI3Kα/δ/β inhibitor | 26 [41] | 26 |
| AZD5363 | AKT 1/2/3 inhibitor | 4.7 [42] | 5 |
| BBI503 | Stemness kinase inhibitor | – | 2.5 |
| MK-1775 | Wee-1 inhibitor | 2.66 [43] | 3 |
| Sorafenib | Raf-1, B-Raf, VEGFR-2 inhibitor | 12.5 [44] | 12.5 |
| APR-246 | p53 re-activation/apoptosis induction | 250 [34] | 200 |
| CB5083 | p97 inhibitor | – | 5 |
| Napabucasin | STAT3 inhibitor | 1.5 [45] | 1.5 |