Figure 1.

NSD2 is stimulated in cisplatin-resistant ESCC cells

(A) Cisplatin-resistant and parental KYSE150 cells were treated with different concentrations of cisplatin for 72 h, and cell viability was measured. Bar graphs show the cisplatin IC₅₀ values. (B and C) Measurement of the (B) mRNA and (C) protein levels of NSDs in cisplatin-resistant and parental KYSE150 cells. (D) Measurement of the cisplatin IC₅₀ values in cisplatin-resistant and parental KYSE30 cells. (E) Detection of indicated transcripts in cisplatin-resistant and parental KYSE30 cells by real-time PCR analysis. (F) Detection of NSD2 protein expression in cisplatin-resistant and parental KYSE30 cells. ∗p < 0.05. ns indicates no significance.