Figure 4.

NSD2 depletion increases cisplatin sensitivity in ESCC cells in vivo

ESCC cells stably transfected with shCtrl or shNSD2 were injected into nude mice. In the drug treatment groups, 3 mg/kg cisplatin was injected. (A and E) Representative images of subcutaneous xenograft tumors from 2 mice of each group. (B and F) Tumor growth curves were plotted. (C and G) Quantitative analysis of the weight of xenograft tumors. (D and H) TUNEL staining showed that NSD2 depletion increased cisplatin-induced apoptosis in xenograft tumors. ∗p < 0.05.