Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Dec 10;23:592–602. doi: 10.1016/j.omtn.2020.12.007

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2020 The Authors

This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

PMC Copyright notice

NSD2-induced cisplatin resistance requires the upregulation of MACC1-AS1 and FOXD2-AS1

(A) Quantitative real-time PCR analysis of MACC1-AS1, FOXD2-AS1, and DANCR levels in NSD2-overexpressing cells. (B) ChIP analysis of the enrichment of H3K36me2 at the promoter regions of indicated genes in control vector and NSD2 overexpression KYSE150 cells. (C) Quantitative real-time PCR analysis of MACC1-AS1, FOXD2-AS1, and DANCR levels after transfection with indicated shRNAs. (D) Measurement of the cisplatin IC₅₀ values in KYSE150 cells transfected with indicated constructs. (E) Quantitative real-time PCR analysis of MACC1-AS1 and FOXD2-AS1 levels in KYSE30 cells transfected with indicated shRNAs. (F) Measurement of the cisplatin IC₅₀ values in KYSE30 cells transfected with indicated constructs. (G) Measurement of the cisplatin IC₅₀ values in cisplatin-resistant KYSE150 and KYSE30 cells transfected with indicated constructs. ∗p < 0.05. ns indicates no significance.