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. 2020 Nov 24;40(3):475–491. doi: 10.1038/s41388-020-01560-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — The unenveloped double stranded murine polyomavirus was discovered in 1953. The viral antigen with transformative capacity, the middle T (PyMT), was identified in 1981. Our lab published the first highly metastatic mammary tumor model expressing PyMT in the mammary gland in an FVB/NJ background. Introduction of MMTV-Cre to the field of oncomice in 1997 allowed for conditional ablation within the mammary epithelium. Mutant PyMT strains in 1998 were instrumental in dissection of PyMT associated signaling. The MTB strain was introduced in 2002 which is used to drive expression of the PyMT coupled to Cre recombinase in the tetO-MIC published in 2014.