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. 2021 Jan 8;11:577129. doi: 10.3389/fimmu.2020.577129

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Copyright © 2021 Lu, Zheng, Wang, Xu, Xie, Yuan, Wang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The proliferation of CD3⁺ T cells and CD4⁺ T cells in mice spleen were induced by T. pallidum. T-cell subpopulation immunotyping and activation status determination of mouse splenocytes after 11 days of infection were performed by flow cytometry. (A) CD3+, (B) CD4+, (C) CD8+, (D) CD4+ naive, (E) CD4+ effector, (F) CD4+ memory, (G) CD8+ naive, (H) CD8+ effector, (I) CD8+ memory. (Ctr, uninfected mice; Inf, infected mice; n = 4-5; mean ± SD; *P < 0.05; **P < 0.01).