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. 2021 Jan 8;11:619878. doi: 10.3389/fmicb.2020.619878

FIGURE 2.

FIGURE 2

Hyphal formation was required for the colonization and dissemination of C. albicans in Rag2γc mice. Rag2γc (RAG; n = 12) or B6 (n = 8) mice were infected by oral gavage with either the wild-type SC5314 strain or the HLC54 filamentation-defective mutant of C. albicans. The fecal fungal counts (A), body weight (B), and survival rates (C) from three independent animal experiments are combined and presented as the mean values with SD. SC5314-infected Rag2γc mice were sacrificed when they became moribund. (D) Tissues, including the kidneys (K), liver (Li), stomach (ST), small intestine (S. Int), ileum (Ile), and colon (Col) tissues, were collected and homogenized, and the homogenates were used for cultures. The numbers of colonies were normalized to the tissue weights and are presented for each individual mouse (dots) and as the average values for mice with positive cultures (black line). For statistical analysis, 1-way ANOVA (A,B) and the Mantel-Cox test (C) were used (*, **, and ***, for p < 0.05, p < 0.01 and p < 0.001, respectively).