Table 2.

Reasons of protocol discontinuation and post-protocol treatment details

Reason of protocol discontinuation	n = 46	Post-treatment details	n = 46	%
Surgery	8	R0 resection	5	10.9
		R2 resection	3	6.5
Patient's withdrawal	1	FOLFIRI + Bmab	1	2.2
Disease progression	1	FOLFOXIRI + Bmab	1	2.2
Adverse event	9	FOLFOXIRI ± Bmab	4	8.7
		FOLFIRI + Bmab	2	4.3
		FL + Bmab	1	2.2
		Capecitabine + Bmab	1	2.2
		BSC	1	2.2
Protocol completion*	27	FOLFOXIRI + Bmab	18	39.1
		FOLFIRI ± Bmab	8	17.4
		FL + Bmab	1	2.2

*Treatment performed in the 12th cycle of protocol therapy

R0 resection curative resection, Bmab bevacizumab, FL infusional 5-fluorouracil and leucovorin, BSC best supportive care