Table 3.
Tumor response (ORR, ETS, DoR), TTF, PFS, and OS
| Variable | All (n = 44) |
Location | RAS status* | ||
|---|---|---|---|---|---|
| Right-sided colon (n = 10) |
Left-sided colon (n = 34) |
Wild (n = 15) |
Mutated (n = 24) |
||
| Overall response rate (ORR) | |||||
|
No. of pts (%) (95% CI) |
28 (63.6) (47.8–77.6) |
7 (70.0) (34.8–93.3) |
21 (61.8) (43.6–77.8) |
11 (73.3) (44.9–92.2) |
15 (62.5) (40.6–81.2) |
| Early tumor shrinkage (ETS) | |||||
|
No. of pts (%) (95% CI) |
31 (70.5) (54.8–83.2) |
7 (70.0) (34.8–93.3) |
24 (70.6) (52.5–84.9) |
11 (73.3) (44.9–92.2) |
17 (70.8) (48.9–87.4) |
| Deepness of response (DoR) | |||||
|
Median % (95% CI) |
45.4 (37.8–49.9) |
44.7 (31.1–64.7) |
45.4 (36.1–49.3) |
47.6 (39.3–61.1) |
45.2 (34.1–50.8) |
| Time to treatment failure (TTF) | |||||
|
Median months (95% CI) |
8.1 (5.3–10.1) |
11.5 (8.2–24.1) |
6.4 (4.2–9.7) |
11.4 (7.6–15.5) |
6.8 (4.2–9.3) |
| Progression-free survival (PFS) | |||||
|
Median months (95% CI) |
15.5 (11.5–23.4) |
24.1 (11.5–26.2) |
14.9 (10.1–22.9) |
13.2 (11.4–24.1) |
17.9 (13.7–26.2) |
| Overall survival (OS) | |||||
|
Median months (95% CI) |
34.4 (26.4-NR) |
26.4 (26.2-NR) |
34.4 (23.6-NR) |
37.1 (23.6-NR) |
29.8 (26.2-NR) |
Right-sided colon cecum, ascending and transverse colon, Left-sided colon descending, sigmoid colon, and rectum, No. number, pts patients, NR not reached
*Five patients with unknown RAS status were excluded