Table 3.
Clinical outcome parameters of studies using laser monotherapy compared with non-surgical mechanical instrumentation alone
| First author (year) | Group | Time point | PPD (mm) | PPD change (mm) | CAL (mm) | CAL change (mm) | GR (mm)/GR change^ (mm) | BOP (%) | BOP change (%) |
GI | PI (%) or PLI/PLI change^ |
|---|---|---|---|---|---|---|---|---|---|---|---|
| Schwarz (2001) | Test | Baseline | 4.9 ± 0.7 | - | 6.3 ± 1.1 | - | 1.4 ± 0.8 | 56 | - | 1.9 ± 0.6 | 1.0 ± 0.6 |
| 6 months | 2.9 ± 0.6* | 2.0 ± 0.64# | 4.4 ± 1.0* | 1.9 ± 0.86# | 1.5 ± 0.7* | 13* | - | 0.3 ± 0.6 | 0.7 ± 0.4 | ||
| Control | Baseline | 5.0 ± 0.6 | - | 6.5 ± 1.0 | - | 1.5 ± 0.8 | 52 | - | 1.9 ± 0.6 | 1.0 ± 0.6 | |
| 6 months | 3.4 ± 0.7 | 1.6 ± 0.64# | 5.5 ± 1.0 | 1.0 ± 0.81# | 2.0 ± 0.8 | 23 | - | 0.4 ± 0.8 | 0.7 ± 0.5 | ||
| Schwarz (2003) | Test | Baseline | 4.9 ± 0.7 | - | 6.3 ± 1.1 | 1.4 ± 0.8 | 56 | - | 1.0 ± 0.6 | ||
| 12 months | 3.0 ± 0.8* | 1.9 | 4.5 ± 1.3* | 1.5 ± 0.7* | 14 | - | 0.6 ± 0.4 | ||||
| 24 months | 3.3 ± 0.9* | 1.6 | 4.9 ± 1.0* | -0.11, 1.12, 3.33 | 1.6 ± 0.7* | 20 | 1.3 ± 0.6 | ||||
| Control | Baseline | 5.0 ± 0.6 | - | 6.5 ± 1.0 | 1.5 ± 0.8 | 52 | - | 1.0 ± 0.6 | |||
| 12 months | 3.5 ± 1.3 | 1.5 | 5.6 ± 1.4 | 2.1 ± 0.7 | 26 | - | 0.7 ± 0.5 | ||||
| 24 months | 3.7 ± 0.7 | 1.3 | 5.8 ± 1.0 | -0.71, 0.82,1.93 | 2.1 ± 0.7 | 28 | 1.2 ± 0.6 | ||||
| Sculean (2004) | Test | Baseline | 5.28 ± 0.6 | - | 6.78 ± 1.03 | 1.11 ± 0.59 | 1.49 ± 0.75 | 40 | - | 0.78 ± 0.15 | |
| 6 months | - | 1.52 ± 0.57 | - | 0.6 ± 0.42, 1.8 ± 1.73 | -0.41 ± 0.16^ | - | 23 | 0.02 ± 0.13^ | |||
| Control | Baseline | 5.33 ± 0.6 | - | 6.74 ± 0.85 | 1.11 ± 0.46 | 1.41 ± 0.6 | 46 | - | 0.81 ± 0.16 | ||
| 6 months | - | 1.57 ± 0.46 | - | 0.6 ± 0.52, 1.9 ± 1.73 | -0.46 ± 0.20^ | - | 31 | 0 ± 0.12^ | |||
| Crespi (2007) | Test | Baseline2 | 5.49 ± 0.27 | - | 6.27 ± 0.51 | - | - | - | - | 1.75 ± 0.58 | 1.05 ± 0.51 |
| 12 months2 | 2.60 ± 0.37* | 2.89 | 3.32 ± 0.64* | 2.95 | - | - | - | 0.64 ± 0.42 | 1.26 ± 0.57 | ||
| 24 months2 | 2.61 ± 0.54* | 2.88 | 3.35 ± 0.91* | 2.92 | - | - | 1.09 ± 0.61 | 1.29 ± 0.48 | |||
| Control | Baseline2 | 5.12 ± 0.39 | - | 6.18 ± 0.42 | - | - | - | - | 1.75 ± 0.58 | 1.05 ± 0.51 | |
| 12 months2 | 4.02 ± 0.65 | 1.10 | 4.89 ± 0.55 | 1.29 | - | - | - | 0.63 ± 0.35 | 1.27 ± 0.64 | ||
| 24 months2 | 4.12 ± 0.74 | 1.00 | 4.86 ± 0.52 | 1.32 | - | - | - | 1.01 ± 0.76 | 1.28 ± 0.65 | ||
| Test | Baseline3 | 7.92 ± 0.78 | - | 8.41 ± 0.47 | - | - | - | - | 1.75 ± 0.58 | 1.05 ± 0.51 | |
| 12 months3 | 3.11 ± 0.41* | 4.01 | 4.40 ± 1.01* | 5.10 | - | - | - | 0.64 ± 0.42 | 1.26 ± 0.57 | ||
| 24 months3 | 3.05 ± 0.53* | 4.87 | 3.38 ± 0.79* | 5.03 | - | - | 1.09 ± 0.61 | 1.29 ± 0.48 | |||
| Control | Baseline3 | 7.13 ± 0.53 | - | 8.35 ± 0.33 | - | - | - | - | 1.75 ± 0.58 | 1.05 ± 0.51 | |
| 12 months3 | 4.82 ± 0.37 | 2.59 | 6.33 ± 0.61 | 2.02 | - | - | - | 0.63 ± 0.35 | 1.27 ± 0.64 | ||
| 24 months3 | 4.85 ± 0.64 | 2.28 | 6.34 ± 0.92 | 2.01 | - | - | - | 1.01 ± 0.76 | 1.28 ± 0.65 | ||
| Kamma (2009) | Test | Baseline | 5.93 ± 1.16 | - | 6.87 ± 1.60 | - | - | 50.7 | - | - | 83.7 |
| 6 months | 3.93 ± 1.31 | 2.00 ± 1.20# | 4.93 ± 1.62 | 1.94 ± 1.31# | - | 31.6 | - | - | 23.2 | ||
| Control | Baseline | 6.47 ± 1.35 | - | 7.07 ± 1.58 | - | - | 54.1 | - | - | 81.6 | |
| 6 months | 4.13 ± 1.6 | 2.34 ± 1.45# | 5.20 ± 1.66 | 1.87 ± 1.32# | - | 32.6 | - | - | 25.8 | ||
| Rotundo (2010) | Test | Baseline | 5.2 ± 1.2 | - | 6.2 ± 1.8 | - | 0.9 ± 1.2 | 75 | - | - | 64 |
| 6 months | 4.5 ± 1.9 | 0.7 ± 1.6 | 6.0 ± 2.4 | 0.2 ± 1.9 | 1.5 ± 1.4 | 58 | - | - | 42 | ||
| Control | Baseline | 5.2 ± 1.2 | - | 6.1 ± 1.6 | - | 0.8 ± 1.1 | 73 | - | - | 68 | |
| 6 months | 4.3 ± 1.7 | 1.0 ± 1.5 | 5.6 ± 2.0 | 0.5 ± 1.8 | 1.3 ± 1.3 | 57 | - | - | 48 | ||
| Wang (2017) | Test | Baseline2 | 4.73 ± 0.63 | - | 5.03 ± 0.53 | - | - | - | - | 3.19 ± 0.37 | 2.48 ± 0.78 |
| 6 months2 | 3.55 ± 0.55 | 1.18 | 4.24 ± 0.74 | 0.79 | - | - | - | 1.87 ± 0.84 | 2.38 ± 0.74 | ||
| Baseline3 | 7.34 ± 0.53 | - | 7.69 ± 1.05 | - | - | - | - | 4.01 ± 0.39 | 2.59 ± 0.75 | ||
| 6 months3 | 4.96 ± 1.30 | 2.38 | 5.63 ± 1.50 | 2.06 | - | - | - | 2.41 ± 0.91 | 2.47 ± 0.75 | ||
| Control | Baseline2 | 4.78 ± 0.79 | - | 5.03 ± 0.46 | - | - | - | - | 3.24 ± 0.25 | 2.50 ± 0.81 | |
| 6 months2 | 3.38 ± 0.70* | 1.4 | 4.24 ± 0.74 | 0.79 | - | - | - | 1.81 ± 0.64 | 2.30 ± 0.75 | ||
| Baseline3 | 7.29 ± 0.34 | - | 7.64 ± 0.90 | - | - | - | - | 4.03 ± 0.19 | 2.56 ± 1.79 | ||
| 6 months3 | 5.23 ± 0.93 | 2.06 | 5.66 ± 1.35 | 1.98 | - | - | - | 2.33 ± 1.00 | 2.48 ± 0.78 | ||
| Grezch (2018) | Test1 | Baseline | 2.53 ± 0.15 | - | 3.45 ± 0.19 | - | 0.91 ± 0.17 | 18.7 ± 1.20 | - | - | 10.3 ± 1.27 |
| Er-YAG | 6 months | 2.01 ± 0.11 | 0.52 ± 0.13# | 3.15 ± 0.21 | 0.47 ± 0.10 | 1.15 ± 0.16 | 10.6 ± 1.79* | - | - | 6.15 ± 1.39* | |
| Test2 NdErNd | Baseline | 2.43 ± 0.19 | - | 3.19 ± 0.19 | - | 0.75 ± 0.11 | 15.85 ± 1.42 | - | - | 9.16 ± 1.11 | |
| 6 months | 1.73 ± 0.12* | 0.70 ± 0.16# | 2.72 ± 0.18* | 0.69 ± 0.13 | 1.02 ± 0.12 | 7.4 ± 1.04* | - | - | 4.05 ± 0.42* | ||
| Control | Baseline | 2.31 ± 0.16 | - | 3.30 ± 0.21 | - | 0.99 ± 0.14 | 17.57 ± 1.58 | - | 9.89 ± 1.45 | ||
| 6 months | 2.01 ± 0.17 | 0.30 ± 0.16# | 3.05 ± 0.21 | 0.73 ± 0.10 | 1.04 ± 0.14 | 16.01 ± 1.41 | - | 8.10 ± 0.79 |
If not otherwise indicated, parameters are presented as means ± standard deviation
1For shallow sites (1–3 mm); 2for moderately deep sites (4–6 mm); 3for deep sites (> 7 mm); * statistically significant (p < 0.05); #data calculated according to the formula in Cochrane workbook, using correlation coefficient calculated from the study of Rotundo 2010 (i.e., 0.53 for PPD change and 0.67 for CAL change)