. 2020 Oct 12;108(2):196–206. doi: 10.1007/s00223-020-00763-7

Table 2.

Demographic baseline of the studies (NR: not reported)

Author, year	Follow-up (months)	Type of treatment	Type of protocol	Samples (n)	Mean age	Female gender (%)
Ahrengart et al. 1994 [22]	12	Ibuprofen	1500 mg daily/9 days	21	70.0	52.6
Ahrengart et al. 1994 [22]	12	Placebo	Placebo	26	70.0	52.6
Barthel et al. 2002 [23]	12	Meloxicam	7.5 mg daily/14 days	24	65.0	42.3
		Meloxicam	15mg daily/14 days	115	63.0	65.0
		Indomethacin	100 mg daily/14 days	111	63.0	64.2
Burssens et al. 1995 [24]	6	Tenoxicam	10 mg daily/42 days	27	61.0
		Tenoxicam	20 mg daily/42 days	26	59.0
		Placebo	Placebo	27	62.0
Dorn et al. 1998 [25]	12	Indomethacin	150 mg daily/4 days	104		61.5
Dorn et al. 1998 [25]	12	Indomethacin	150 mg daily/8 days	105		60.0
Elmstedt et al. 1985 [26]	12	Ibuprofen	1200 mg daily/92 days	21	70.0	52.4
Elmstedt et al. 1985 [26]	12	Placebo	Placebo	21	70.0	60.0
Fransen et al. 2006 [27]	12	Ibuprofen	1200 mg daily/14 days	391	66.0	45.0
Fransen et al. 2006 [27]	12	Placebo	Placebo	407	67.0	45.6
Gebuhr et al. 1991 [28]	12	Naproxen	750 mg daily/28 days	28	75.0	60.7
Gebuhr et al. 1991 [28]	12	Placebo	Placebo	27	70.0	55.5
Gebuhr et al. 1996 [29]	12	Tenoxicam	40/20 mg daily/5 days	61	72.0
Gebuhr et al. 1996 [29]	12	Placebo	Placebo	62	72.0
Grohs et al. 2007 [30]	12.0	Rofecoxib	25 mg daily/7 days	50	60.0	66.0
Grohs et al. 2007 [30]	12.0	Indomethacin	100 mg per daily/7 days	50	60.0	60.0
Kienapfel et al. 1999 [31]	18	Indomethacin	100 mg daily/42 days	55	64.4	60.0
Kienapfel et al. 1999 [31]	18	Control group	No treatment	50	66.0	76.0
Kjaersgaard-Andersen et al. 1993 [32]	3	Indomethacin	100 mg daily/14 days	34	72	68.4
Kjaersgaard-Andersen et al. 1993 [32]	3	Placebo	Placebo	34	70	63.6
Knelles et al. 1997 [33]	12	Indomethacin	100 mg daily/14 days	90	67.0	68.0
		Indomethacin	100 mg daily/7 days	113	64.7	72.0
		Acetylsalicylic acid	2250 mg daily/14 days	93	66.5
		Control group	No treatment	100	65.3	69.0
Kölbl et al. 1997 [34]	12	Indomethacin	100 mg daily/7 days	113	64.7	63.7
Kölbl et al. 1997 [34]	12	Control group	No treatment	100	65.3	69.0
Kölbl et al. 1998 [35]	6	Diclofenac	150 mg daily/14 days	54	63.9	51.8
Kölbl et al. 1998 [35]	6	Control group	No treatment	100	65.3	69.0
Legenstein et al. 2003 [36]	6	Indomethacin	150 mg daily/12 days	58	68.0	59.0
Legenstein et al. 2003 [36]	6	Meloxicam	7.5 mg daily/12 days	58	65.0	74.0
Neal et al. 2000 [37]	9	Acetylsalicylic acid	162 mg daily/35 days	1039	66.0	50.0
Neal et al. 2000 [37]	9	Placebo	Placebo	1009	65.0	51.0
Persson et al. 1998 [38]	12	Ibuprofen	1200 mg daily/21 days	48		50.0
		Ibuprofen	1200 mg daily/7 days	48		50.0
		Placebo	Placebo	47		53.3
Reis et al. 1992 [39]	24	Diclofenac	150 mg daily/42 days	80
Reis et al. 1992 [39]	24	Placebo	Placebo	80
Saudan et al. 2007 [40]	3	Celecoxib	400 mg daily/10 days	117	69.0	53.0
Saudan et al. 2007 [40]	3	Ibuprofen	1200 mg daily/10 days	123	70.0	54.0
Schmidt et al. 1988 [41]		Indomethacin	75 mg daily/42 days	102	67.0
Schmidt et al. 1988 [41]		Placebo	Placebo	99	68.0
Van der Heide et al. 2004 [42]	6	Indomethacin	150 mg daily/7 days	89	67.0	68.5
		Meloxicam	15 mg daily/7 days	92	67.0	68.5
		Control group	No treatment	170
Van der Heide et al. 2007 [43]	12	Indomethacin	150 mg daily/7 days	89		62.4
Van der Heide et al. 2007 [43]	12	Rofecoxib	50 mg daily/7 days	85		62.4
Vielpeau et al. 1999 [44]	6	Naproxen	750 mg daily/42 days	28	66.0
		Indomethacin	75 mg daily/42 days	28	63.9
		Placebo	Placebo	28	62.8
Wahlstrom et al. 1991 [45]	24	Diclofenac	150 mg daily/42 days	50	71.0	40.0
Wahlstrom et al. 1991 [45]	24	Placebo	Placebo	50	70.0	39.1
Winkler et al. 2016 [46]	6	Diclofenac	150 mg daily/9 days	44	61.9	45.8
Winkler et al. 2016 [46]	6	Etoricoxib	90 mg daily/9 days	45	60.2	46.8
Zhao et al. 2011 [47]	1.5	Celecoxib	200 mg daily/42 days	25	65.4
Zhao et al. 2011 [47]	1.5	Indomethacin	75 mg daily/42 days	25	65.4