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. 2021 Jan 21;11:2062. doi: 10.1038/s41598-021-81629-2

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Longitudinal analysis SARS-CoV-2 neutralizing antibodies in patients with varying severity of COVID-19. SARS-CoV-2 NAbs were measured in those with severe (n = 6), moderate (n = 5) and mild/asymptomatic illness (n = 13) and also those who had mild illness but with prolonged shedding of the virus (n = 21) (A). In order to assess the timing of the NAb responses at different time point, these antibodies were measured in patients with severe pneumonia (n = 10), moderate illness (n = 19), mild illness (n = 150) and prolonged shedding (n = 82). The NAbs levels were determined in this larger cohort of individuals during the first 3 weeks and during week 4 to 8 of illness (B). The black dotted line indicates the cut-off value of a positive result.