Table 1.
Molecules | Full name | Alternate name | Binding partners | Expressed cells | References |
---|---|---|---|---|---|
CTLA-4 | Cytotoxic T lymphocyte-associated protein-4 | CD152 |
CD80 (B7-1) CD86 (B7-2) |
T cells | 5,139 |
PD-1 |
Programmed cell-death protein-1 |
CD279 |
PD-L1 (B7-H1 or CD274) PD-L2 (B7-DC or CD273) |
T cells, NKT cells, B cells, monocytes, Langerhans’ cells |
16,140 |
LAG-3 | Lymphocyte activation gene-3 | CD223 |
MHC-II FGL1 galectin-3 (LGALS3) LSECtin α-synuclein |
T cells, B cells, Tregs, NK cells, NKT cells, pDCs |
5,141,142 |
TIGIT |
T-cell immunoglobulin and ITIM domain |
WUCAM Vstm3 Vsig9 |
CD155 (PVR, Necl-5) CD112 (nectin-2, PRR2, PVRL2) |
T cells, Tregs, NK cells, | 143–145 |
TIM-3 |
T-cell immunoglobulin and mucin-domain containing-3 |
HAVCR2 CD366 |
Galectin-9 Ceacam-1 HMGB-1 PtdSer |
T cells, Tregs, DCs, NK cells, monocytes, macrophages |
5,18,144–146 |
BTLA |
B and T cell lymphocyte attenuator |
CD272 | HVEM |
B cells, T cells, macrophages, DCs |
147,148 |
VISTA |
V-domain Ig suppressor of T cell activation |
PD-1H DD1α Gi24 Dies1 B7-H5 |
VSIG-3 | APCs, T cells, Tregs | 5,149 |
B7-H3 | B7 homolog 3 protein | CD276 |
IL20RA TLT2 (putative) |
T cells, B cells, APCs, NK cells, DCs, monocytes, fibroblasts, epithelial cells, tumor cells |
5,145,150–153 |
B7-H4 | B7 homolog 4 protein | VTC1 B7x B7S1 | unknown | T cells, B cells, monocytes, DCs | 145,154,155 |
KIR | Killer-cell immunoglobulin-like receptor | CD158 | MHC class I molecules | NK cells, T cells | 111,156 |
CD160 | Cluster of differentiation 160 | – | HVEM |
NK cells, T cells, intraepithelial lymphocytes |
157 |
CD73 | Cluster of differentiation 73 |
ecto-5’- nucleotidase |
Dephosphorylating extracellular AMP to generate adenosine |
Tumor cells, Th cells, Tregs, T cells, B cells, macrophages, DCs |
158,159 |
CD96 | Cluster of differentiation 96 | – |
CD111 CD155 |
T cells, NK cells, NKT cells | 160,161 |