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. 2021 Jan 21;12(1):112. doi: 10.1038/s41419-020-03350-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a PTC cell lines were cotransfected with stable sh-NC and inhibitor-NC or sh-circRUNX1 and inhibitor-NC or sh-circRUNX1 and miR-296-3p inhibitor. The migration and invasion potential was evaluated by Transwell migration and Matrigel invasion assays. Scale bars = 100 μm. b Representative images showing the reversion of the migration ability upon miR-296-3p downregulation by wound-healing assay. c Colony formation assay exhibiting changes in the proliferation capacity of stable sh-circRUNX1 or sh-NC PTC cells transfected with or without the miR-296-3p inhibitor. d The CCK-8 assay revealed that the effect of circRUNX1 knockdown on cell growth was abrogated by miR-296-3p downregulation. Data represent the mean ± SD from three independent experiments (a–d) (*P < 0.05 by Student’s t-test).