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. 2021 Jan 21;11:1996. doi: 10.1038/s41598-021-81689-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Gene co-expression networks in the MBH of immature female rats injected with either LV-GFP or LV-EED in the ARC. (A) First and second-neighbor network of strong co-expression edges for Kiss1 and Kdm6b. Positively correlated edges are red, negatively correlated edges are green. First neighbors involved in primarily negative epigenomic regulation are indicated in light green ovals, while positive epigenomic regulators are indicated in red ovals. Non-epigenetic genes are blue ovals. Glutamatergic-related genes are indicated in yellow ovals, other in cyan ovals. (B) Histogram depicting expression correlations of pairs of genes involved in positively correlated strong co-expression relationships with Kdm6b, Kiss1, Nell2 and Grm7 under control conditions (blue bars) and after EED overexpression (yellow bars).