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. 2021 Jan 21;11:1996. doi: 10.1038/s41598-021-81689-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Changes in Gene Expression and recruitment of EED and H3K27me3 to the promoter of network genes. (A) Gene expression in R22 cells stably expressing EED. mRNA levels were measured by qPCR. Results are expressed as fold change with respect to control LV-GFP group. *p < 0.05, ***p < 0.001 vs. LV-GFP- Control (n = 4 per group). (B) Recruitment of EED to the promoters of Kiss1 and Kdm6b in R22 cells overexpressing EED. (C) Increased H3K27me3 abundance at the promoter of Kiss1 and Kdm6b in R22 cells after EED overexpression. Results are expressed as fold-change with respect to cells transduced with LV-GFP. *p < 0.05, **p < 0.01, ***p < 0.001 vs. LV-GFP treated cells (Student’s t-test) (n = 4 per group).