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. 2021 Jan 21;7:3. doi: 10.1038/s41540-020-00168-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — From left to right: Distribution of the number of total interactions, the size of the largest connected component (LCC), and the number of edges in the LCC in the subgraph induced by a randomly selected gene set of the same size and degree distribution as the original disease list of the switch genes in the human interactome. Dashed red lines correspond to the observed values of each metric computed for the list of switch genes mapped to the interactome. All p-values were calculated by using a one-tailed z test.