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. 2021 Jan 21;12:498. doi: 10.1038/s41467-020-20603-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Overview of 62 tumour and three control DNA methylation classes included in the sarcoma classifier reference cohort. The methylation classes are colour-coded and grouped according to the WHO scheme. The relation between methylation classes and the WHO defined subtypes is categorised in 4 tiers: equivalent to a WHO entity (category 1); subgroup of a WHO entity (category 2); combining WHO entities (category 3); non-defined by WHO (category 4). b Visualisation of the reference cohort methylation profiles (n = 1,077) using t-distributed stochastic neighbour embedding (t-SNE) dimensionality reduction. Individual samples are colour-coded in the respective class colour (n = 65) as given in (a). Abbreviations: LIPO, lipoma; MLS, myxoid liposarcoma; WDLS/DDLS, well differentiated liposarcoma/dedifferentiated liposarcoma; NFA, nodular fasciitis; MO, myositis ossificans; MP, myositis proliferans; DTFM, desmoid-type fibromatosis; DFSP, dermatofibrosarcoma protuberans; SFT, solitary fibrous tumour; IMT, inflammatory myofibroblastic tumour; IFS, infantile fibrosarcoma; LGFMS, low-grade fibromyxoid sarcoma; SEF, sclerosing epithelioid fibrosarcoma; LMO, leiomyoma; LMS, leiomyosarcoma; RMS (EMB), embryonal rhabdomyosarcoma; RMS (ALV), alveolar rhabdomyosarcoma; RMS (MYOD1); rhabdomyosarcoma with MYOD1 mutation; ALMO/MPC, angioleiomyoma/myopericytoma; EHE, epithelioid haemangioendothelioma; AS, angiosarcoma; GIST, gastrointestinal stromal tumour; SWN, schwannoma; NFB, neurofibroma; NFB (PLEX), plexiform neurofibroma; MPNST, malignant peripheral nerve sheath tumour; AFX/PDS, atypical fibroxanthoma/pleomorphic dermal sarcoma; AFH, angiomatoid fibrous histiocytoma; OFMT, ossifying fibromyxoid tumour; SYSA, synovial sarcoma; ES, epithelioid sarcoma; ASPS, alveolar soft part sarcoma; CCS, clear cell sarcoma of soft parts; EMCS, extraskeletal myxoid chondrosarcoma; DSRCT, desmoplastic small round cell tumour; MRT, malignant rhabdoid tumour; USARC, undifferentiated sarcoma; CCSK, clear cell sarcoma of the kidney; ESS (LG), low-grade endometrial stromal sarcoma; ESS (HG), high-grade endometrial stromal sarcoma; SCC (CUT), cutaneous squamous cell carcinoma; MEL (CUT), cutaneous melanoma; SARC, sarcoma; CTRL, control; MUS, muscle tissue; REA, reactive tissue; CB, chondroblastoma; CSA, chondrosarcoma; CSA (MES), mesenchymal chondrosarcoma; CSA (CC), clear cell chondrosarcoma; OB, osteoblastoma; OS (HG), high-grade conventional osteosarcoma; SBRCT, small blue round cell tumour; GCTB, giant cell tumour of bone; CHORD, chordoma; DD, dedifferentiated; FDY, fibrous dysplasia; LCH, Langerhans cell histiocytosis.