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. 2021 Jan 21;12(1):109. doi: 10.1038/s41419-020-03385-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Kidney tissue from sham-operated (Sham) or unilateral ureteral obstruction (UUO) mice was tested by Masson staining (100×) and immunohistochemical analysis of α-SMA, F4/80, VEGF-C, and LYVE-1 (400×). There was a positive correlation between the number of LYVE-1⁺ vessels and the positive area (%) of α-SMA (B), F4/80 (C), and VEGF-C (D). E Protein expression of fibrosis markers (α-SMA, collagen 1, and PDGFR-β) and lymphangiogenesis markers (LYVE-1, Prox-1, and VEGF-C) in Sham and UUO mouse kidneys were measured by western blotting. F Quantitative analysis of the results in (E) was conducted to show the protein expression of fibrosis markers (α-SMA, collagen 1, and PDGFR-β) and lymphangiogenesis markers (LYVE-1, Prox-1, and VEGF-C) in Sham and UUO mouse kidneys. *p < 0.05, **p < 0.01 versus the Sham group. G–L Relative mRNA expression of Collagen 1 (G), α-SMA (H), PDGFR-β (I), Prox-1 (J), VEGF-C (K), and LYVE-1 (L) in Sham and UUO mouse kidneys was measured by real-time PCR; *p < 0.05, **p < 0.01 versus the Sham group. N = 6/group.