Table 3.
Demographic and clinical characteristics of the samples.
| Humans | ||||||
|---|---|---|---|---|---|---|
| Healthy (H) | OCD | BF10 | Checkers (C) | Non-checkers (NC) | BF10 | |
| Sample size | 40 | 40 | 21 | 19 | ||
| Gender (M/F) | 15/25 | 15/25 | 0.26 | 10/11 | 5/14 | 0.44 |
| Hand (R/L) | 35/5 | 34/6 | 0.2 | 16/5 | 18/1 | 0.34 |
| Age in years | 40.28 (13.59) | 40.15 (13.22) | 0.18 | 41.9 (12.78) | 38.21 (13.77) | 0.15* |
| Education in years | 5.43 (2.19) | 5.15 (2.69) | 0.37 | 5.1 (3.24) | 5.21 (1.99) | 0.13* |
| fNART IQ | 108.18 (6.76) | 107.4 (6.87) | 0.2 | 106.81 (7.12) | 108.05 (6.71) | 0.14* |
| BDI | 0.8 (1.34) | 12.53 (6.56) | >100 | 11.05 (5.09) | 14.16 (7.68) | >100*: H < C = NC |
| BIS-10 | 45 (9.89) | 47.03 (11.75) | 0.23 | 48.57 (12.14) | 45.32 (11.38) | 0.21* |
| STAI-A | 40.40 (4.38) | 62.60 (13.07) | >100 | 62.81 (10.08) | 62.37 (16.04) | >100*: H < C = NC |
| STAI-B | 36.05 (5.97) | 65.38 (9.05) | >100 | 64.76 (5.65) | 66.05 (11.88) | >100*: H < C = NC |
| OCI-R | ||||||
| Total score | 3.88 (4.23) | 30.43 (8.86) | >100 | 31.19 (7.85) | 29.58 (10) | >100*: H < C = NC |
| Order subscore | 1.45 (1.88) | 6.28 (3.06) | >100 | 6.14 (3.14) | 6.42 (3.04) | >100*: H < C = NC |
| Washing subscore | 0.53 (1.06) | 6.45 (4.59) | >100 | 4.43 (4.23) | 8.68 (3.96) | >100*: H < C < NC |
| Checking subscore | 0.35 (0.89) | 5.68 (3.87) | >100 | 8.52 (2.23) | 2.53 (2.65) | >100*: H < NC < C |
| Hoarding subscore | 1.1 (1.37) | 3.85 (2.93) | >100 | 4.29 (2.26) | 3.37 (3.53) | >100*: H < C = NC |
| Obsession subscore | 0.38 (0.77) | 5.53 (2.97) | >100 | 5.1 (2.41) | 6 (3.5) | >100*: H < C = NC |
| Neutralization subscore | 0.18 (0.5) | 2.65 (2.86) | >100 | 2.71 (3.02) | 2.58 (2.76) | >100*: H < C = NC |
| YBOCS | 25.25 (5.29) | 24 (4.84) | 26.63 (5.54) | 0.85 | ||
| Taking an antidepressant | 28 | 16 | 12 | 0.74 | ||
| with an AAP | 4 | 2 | 2 | 0.24 | ||
| with a benzodiazepine | 7 | 4 | 3 | 0.3 | ||
| Fluoxetine-equivalent in mg/d | 53.73 (57.65) | 46.74 (47.88) | 61.45 (67.34) | 0.4 | ||
| Psychiatric comorbidities | ||||||
| Anxiety disorder | 11 | 9 | 2 | 6.27 | ||
| Eating disorder | 1 | 0 | 1 | |||
| Age at onset | 15.23 (5.88) | 15.05 (5.64) | 15.42 (6.28) | 0.31 | ||
| Duration in years | 24.92 (13.95) | 26.86 (15.45) | 22.79 (12.14) | 0.43 | ||
| C57BL/6J mice | ||||||
|---|---|---|---|---|---|---|
| WT (W) | Sapap3 KO | BF10 | Impaired KO (I) | Unimpaired KO (U) | BF10 | |
| Sample size | 26 | 26 | 12 | 14 | ||
| Age in days | 200.12 (12.23) | 199.35 (12.29) | 0.25 | 199.67 (14.9) | 199.07 (10.13) | 0.16* |
| Weight in g | 35.47 (4.99) | 29.71 (2.88) | >100 | 29.13 (3.32) | 30.21 (2.46) | >100*: W > I = U |
| Number of grooming bouts | 5.38 (3.75) | 12.12 (7.05) | >100 | 14.58 (8.55) | 10 (4.82) | >100*: W < I = U |
| Time spent grooming in % | 11.76 (19.18) | 25 (20.43) | 3.11 | 29.01 (24.2) | 21.56 (16.72) | 1.71*: W < I = U |
Mean values (with standard deviation) of demographic and clinical characteristics for human and mice populations. A BF10 greater than one is in favor of a difference (and vice versa). The further the BF10 is from one, the greater the evidence (and vice versa). A BF10 greater than 3 (or lower than 1/3) is commonly considered a significant evidence. The * indicates a JZS ANOVA BF10 with the results of post hoc tests given after the BF10 value; “=” indicating an absence of difference. AAP atypical antipsychotic, OCI-R obsessive compulsive inventory revised, YBOCS Yale-Brown obsessive-compulsive scale, BDI Beck depression inventory, STAI Spielberger’s State (A)–trait (B) anxiety inventory, BIS-10 Barratt impulsivity scale, fNART French national adult reading test.