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. 2021 Jan 5;24(1):102019. doi: 10.1016/j.isci.2020.102019

Figure 4.

Figure 4

PKD1 is highly expressed in DCLK1-positive pancreatic lesion cells

(A) IHC-IF for DCLK1 (green) and PKD1 (red), with DAPI nuclear stain in KC mouse pancreas. The scale bars indicate 50 μm.

(B) PKD1 and DCLK1 mRNA expression data with regression line from https://www.cbioportal.org/ using the QCMG dataset containing 96 pancreatic adenocarcinoma samples.

(C) IHC for pY95-phosphorylated PKD in lesions of KC mice.

(D) IHC-IF for pY95-phosphorylated PKD (green) and DCLK1 (pink) in lesions of a KC mouse with DAPI nuclear stain. Scale bars represent 20 μm.

(E) Quantification of the percentage of DCLK1+ cells with or without pY95-PKD (t test p value < 0.0001; n = 4 mice). ∗ indicates statistical significance, and error bars represent standard deviation.