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MSC-derived Notch and Wnt signaling in leukemia: (1) Contact between MSC and leukemia cells; (2) Activation of the Notch and Wnt signaling cascades in MSC; (2) Synthesis of Notch and Wnt target genes including Jagged1; (4) Upregulation of Notch1 and Jagged1 expression; (5) Activation of adhesion molecules and Notch signaling; (6) Release of NICD and stabilization of β-catenin; (7) Transactivation of Notch and Wnt target genes.
