Table 1.

Comparison of histological fibrosis scoring systems

Fibrosis stage	Brunt system [53]	NASH CRN score [48]	SAF score [57]
0	None	None	None
1	Zone 3 perisinusoidal fibrosis; focally or extensively present	1a: Mild (delicate) zone 3 perisinusoidal fibrosis
		1b: Moderate (dense) zone 3 perisinusoidal fibrosis
		1c: Portal fibrosis only
2	Zone 3 perisinusoidal fibrosis with focal or extensive periportal fibrosis	Zone 3 perisinusoidal fibrosis with periportal fibrosis
3	Zone 3 perisinusoidal fibrosis and portal fibrosis with focal or extensive bridging fibrosis	Bridging fibrosis
4	Cirrhosis	Cirrhosis

NASH CRN, Nonalcoholic Steatohepatitis Clinical Research Network; SAF, steatosis activity fibrosis.