Figure 1.

Localized irradiation inhibits the growth of both primary and distant tumors in a syngeneic model of murine hepatocellular carcinoma. (A) Scheme for radiation treatment of a bilateral tumor mouse model established using Hepa 1–6 cells. Growth curves of (B) irradiated tumors and (C) non-irradiated tumors in mice bearing bilateral Hepa 1–6 tumors. Gray arrowheads indicate day 1 of irradiation. (D) Representative images of tumors collected from mice. (E) Survival of mice bearing bilateral Hepa 1–6 tumors for three different treatment groups. RT, radiation therapy. ^*P<0.05. ^†P<0.001.