Table 3.

Nakanuma’s classification: scoring of PBC [81]

	Fibrosis	Bile duct loss	Deposition of orcein-positive granules
Score 0	No or limited portal fibrosis	No	No deposition
Score 1	Portal fibrosis	Yes, in <1/3 of the portal tracts	Deposition in several periportal hepatocytes in <1/3 of the portal tracts
Score 2	Bridging fibrosis	Yes, in 1/3–2/3 of the portal tracts	Deposition in variable periportal hepatocytes in 1/3–2/3 of the portal tracts
Score 3	Cirrhosis	Yes, in >2/3 of the portal tracts	Deposition in many periportal hepatocytes in >2/3 of the portal tracts