Table 5.
Criteria defining biochemical responses to UDCA
| Criteria | Number of patients | Duration | Definition |
|---|---|---|---|
| Qualitative definition | |||
| Barcelona [95] | 192 | 1 year | Normal ALP level or reduction in the ALP level by >40% |
| Paris-I [88] | 292 | 1 year | ALP level <3×ULN, AST level <2×ULN, normal bilirubin level |
| Rotterdam [90] | 375 | 1 year | Normal bilirubin level, normal albumin level |
| Toronto [91] | 69 | 2 year | ALP level ≤1.67×ULN |
| Ehime [86] | 83 | 6 months | Normal GGT level or reduction in the GGT level by ≥70% |
| Paris-II [89] | 165 | 1 year | ALP level <1.5×ULN, AST level <1.5×ULN, normal bilirubin level |
| Rochester [94] | 73 | 1 year | ALP level ≤1.67×ULN, bilirubin level ≤1 mg/dL |
| International (Global PBC) [93] | 4,845 | 1 year | ALP level <2×ULN, normal bilirubin level |
| Quantitative scores | |||
| GLOBE score [92] | 4,119 | 1 year | Bilirubin level, ALP level, albumin level, and platelet count at 1 year, age at baseline |
| UK-PBC score [87] | 3,165 | 1 year | ALP level, AST/ALT level, and bilirubin level at 1 year, albumin level and platelet count at baseline |
UDCA, ursodeoxycholic acid; ALP, alkaline phosphatase; ULN, upper limit of normal; AST, aspartate aminotransferase; ALT, alanine aminotransferase; GGT, gamma glutamyl transferase.