Table 1.

Main characteristics of case–control studies included in the meta-analysis evaluating the association of AML and pesticide exposure.

First author	Year	Country	Inclusion periods	Gender	Inclusion age	AML sourcea	Controls sourcea	Matching criteria	Adjusted ORb	No. AML	No. controls	Exposurec	Quality score (/9)d
Flodin U33	1986	Sweden	1977–1982	M/F	20–70	Multicentric	Population	Age, gender, residency	No	59	354	SAQ	4
Richardson S34	1992	France	1984–1988	M/F	> 30	Multicentric	Hospital	Age, gender, ethnicity, residency	Yes	154	513	PTP	8
Crane MM35	1992	USA	1982–1983	M/F	> 18	Multicentric	Hospital	Age, gender, ethnicity, year of inclusion	No	60	60	PTP	7
Ciccone G36	1993	Italy	1989–1990	M/F	15–74	Monocentric	Hospital and population	Age, gender	Yes	50	246	PTP	6
Mele A37	1994	Italy	1986–1990	M/F	> 15	Multicentric	Hospital	NS	Yes	252	1,161	PTP	4
Albin M38	2000	Sweden	1976–1993	M/F	> 20	Multicentric	Population	Age, gender, residency	No	372	351	PTP	6
Lazarov D39	2000	UK, Yugoslavia	1986–1994	M/F	> 18	Multicentric	Hospital	Age, gender, year of inclusion	No	98	196	PTP	7
Adegoke OJ40	2003	China	1987–1989	M/F	> 15	Multicentric	Population	Age, gender	Yes	236	502	PTP	6
Terry PD41	2005	USA, Canada	1986–1989	M/F	17–79	Multicentric	Population	Age, gender, ethnicity, residency	Yes	599	607	PTP	6
Kaufman DW42	2009	Thailand	1997–2003	M/F	> 18	Monocentric	Hospital	Age, gender, residency	Yes	87	756	PTP	7
Wong O43	2010	China	2003–2007	M/F	> 18	Multicentric	Hospital	Age, gender, hospital	No	722	1,444	PTP	8
Strom SS44	2012	USA	2003–2007	M/F	18–80	Monocentric	Population	Age, gender, ethnicity, residency	No	638	636	PTP	8
Parodi S45	2017	Italy	1990–1993	M/F	20–74	Multicentric	Population	Age, gender	No	223	1,774	PTP	7
Poynter JN46	2017	USA	2005–2010	M/F	20–79	Multicentric	Population	Age	Yes	405	1,348	SAQ	6

^aAcute myeloid leukemia (AML) patients and controls source are described in Table S3; ^bAdjustment variables are fully described in Table S6; ^cPesticide exposure methods are fully described in Table S2; ^dQuality score was evaluated with the Newcastle–Ottawa scale for case–control studies (Table S4). NS: not specified; PTP: person-to-person interview; SAQ: self-administered questionnaire; OR: odds ratio.