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. 2021 Jan 21;11:1957. doi: 10.1038/s41598-021-81396-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Adjusted hazard ratios, 95% confidence intervals, and incidence rates of end-stage renal disease according to changes in the number of metabolic syndrome components as reference with the subjects with 0–1 MetS components at both exams over two years. The model was adjusted for metabolic syndrome components at first visit, age, sex, smoking, alcohol consumption, exercise, and estimated glomerular filtration rate. *The subjects whose the number of MetS components decreased from 4–5 even to 0–1, the HR for the risk of ESRD remained 3.84 (95% CI, 3.17–4.67) compared with subjects who persistently had 0–1 MetS components over two years.