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. 2021 Jan 21;6:13. doi: 10.1038/s41541-020-00274-4

Fig. 5. Cynomolgus monkeys immunized with CIS43 VLPs produce protective anti-CSP antibodies.

Fig. 5

a IgG concentrations in cynomolgus monkeys immunized at weeks 0 and 4 with CIS43 VLPs with or without Advax-3 adjuvant (n = 3/group). Qβ VLPs were used as a negative control. b Parasite liver load (as measured by luminescence) in mice (n = 4–5/group) that received an intravenous injection of 500 µl of sera from immunized cynomolgus monkeys. Two hours following serum transfer, mice were challenged with five Pb-PfCSP-Luc infected mosquitoes. Mann–Whitney test was used to statistically compare each group to the group that received an intravenous injection with PBS. c Percent inhibition of liver infection, as calculated from luminescence data. Inhibition of infection is calculated relative to the mean signal in the control groups. Mann–Whitney test was used to statistically compare each group to all control groups. Error bars represent SEM.