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. 2021 Jan 21;11:1949. doi: 10.1038/s41598-020-80102-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Weighted Correlation Network Analysis of transcript changes within cardiac allograft biopsies with rejection versus stable [GSE124897]. (a) Gene dendrogram and module colors for the top 5,000 genes with the most significant Wilcoxon test p value, comparing rejection to non-rejection/normal. The top 4 modules (turquoise, yellow, blue and brown) are shown. The branches indicate modules of interconnected gene groups. (b) Distribution of expression of genes within the Turquoise Module in biopsies with rejection versus non-rejection/normal. (c–e) Violin plots show the expression of inflammatory effector molecules and of leukocyte receptors for endothelial adhesion molecules in normal cardiac transplant biopsies and those with TCMR or ABMR. The backtransformed values for intragraft (c) proinflammatory cytokines TNF and IL1B. (d) endothelial adhesion and recruitment genes VCAM1, BST2, CD164/endolyn, CXCL1/GROα, CXCL9/MIG, CXCL10/IP-10, CCL2/MCP-1, CXCL8/IL-8; and (e) cognate leukocyte receptors SELPG/PSGL-1, ITGB2/LFA-1/Mac-1, and ITGA4/VLA-4 are shown.

Weighted Correlation Network Analysis of transcript changes within cardiac allograft biopsies with rejection versus stable [GSE124897]. (a) Gene dendrogram and module colors for the top 5,000 genes with the most significant Wilcoxon test p value, comparing rejection to non-rejection/normal. The top 4 modules (turquoise, yellow, blue and brown) are shown. The branches indicate modules of interconnected gene groups. (b) Distribution of expression of genes within the Turquoise Module in biopsies with rejection versus non-rejection/normal. (c–e) Violin plots show the expression of inflammatory effector molecules and of leukocyte receptors for endothelial adhesion molecules in normal cardiac transplant biopsies and those with TCMR or ABMR. The backtransformed values for intragraft (c) proinflammatory cytokines TNF and IL1B. (d) endothelial adhesion and recruitment genes VCAM1, BST2, CD164/endolyn, CXCL1/GROα, CXCL9/MIG, CXCL10/IP-10, CCL2/MCP-1, CXCL8/IL-8; and (e) cognate leukocyte receptors SELPG/PSGL-1, ITGB2/LFA-1/Mac-1, and ITGA4/VLA-4 are shown.