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. 2021 Jan 8;8:606643. doi: 10.3389/fped.2020.606643

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Copyright © 2021 Nair and Parker.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Platelet involvement in NETosis and Immunothrombosis: Platelets interact with neutrophils via platelet membrane expressed P-selectin and P-selectin glycoprotein ligand-1 (PSGL-1) expressed on neutrophils with subsequent enhancement of neutrophils, extrusion of neutrophil DNA and formation of Neutrophil Extracellular Traps (NETs) which can serve as a nidus of thrombus formation. Platelet activation via lipopolysaccharide (LPS) binding to platelet Toll-like receptors may also participate in NET formation and NETosis.