Table 5.
Prognostic tumor characteristics in breast cancer patients according to their BMI (obese vs. non-obese).
| Variable | All patients n = 347 (100%) |
Non-obese n = 224 (64.55%) |
Obese n = 123 (35.45%) |
p |
|---|---|---|---|---|
| Clinical tumor size (mm) | 22.63 ± 14.64 | 21.48 ± 14.32 | 23.65 ± 15.13 | 0.36 |
| Pathological tumor size (mm) | 24.23 ± 14.87 | 23.93 ± 16.13 | 24.50 ± 14.56 | 0.76 |
| Tumor size (cm) | ||||
| ≤ 2 cm | 151 (57.85%) | 94 (59.49%) | 57 (55.34%) | 0.04* |
| > 2 cm | 110 (42.15%) | 64 (40.51%) | 46 (44.66%) | |
| Clinical stage | ||||
| I | 115 (41.22%) | 75 (42.37%) | 40 (39.22%) | 0.66 |
| II, III | 143 (51.25%) | 87 (49.16%) | 56 (54.9%) | |
| IV | 21 (7.53%) | 15 (8.47%) | 6 (5.88%) | |
| Pathological stage | ||||
| Initial (I) | 111 (36.75%) | 76 (40%) | 35 (31.25%) | 0.08 |
| Intermediate (II, III) | 168 (55.63%) | 97 (51.05%) | 71 (63.39%) | |
| Advanced (IV) | 23 (7.62%) | 17 (8.95% ) | 6 (5.36% ) | |
| Axillary involvement | ||||
| Negative | 172 (58.50%) | 112 (61.20%) | 54 (46.15%) | 0.04* |
| Positive | 122 (41.5%) | 71 (38.80%) | 63 (53.84%) | |
| Histological type | ||||
| Ductal | 224 (94.12%) | 138 (93.88%) | 86 (94.5%) | 0.69 |
| Lobulillar | 14 (5.88%) | 9 (6.12%) | 5 (5.49%) | |
| Differentiation degree | ||||
| 1, 2 | 196 (71.01%) | 131 (76.61%) | 65 (61.9%) | 0.01* |
| 3 | 80 (28.99%) | 40 (23.39%) | 40 (38.1%) | |
| Lymphovascular invasion (a) | ||||
| Yes | 14 (5.98%) | 14 (9.4%) | 0 | 0.13 |
| No | 220 (94.02%) | 135 (90.6%) | 85 (100%) | |
| Ki-67 (a) (n = 84) | ||||
| (+) | 236 (86.45%) | 151 (85.8%) | 85 (87.63%) | 0.28 |
| (−) | 37 (13.55%) | 25 (14.2%) | 12 (12.37%) | |
| Ki-67 (%) (a) | 24.45 ± 5.10 | 27.69 ± 3.10 | 21.57 ± 7.54 | 0.23 |
| ER | ||||
| (+) | 269 (85.4% ) | 177 (86.76%) | 92 (82.88%) | 0.54 |
| (−) | 46 (14.6% ) | 27 (13.24%) | 19 (17.12%) | |
| PR | ||||
| (+) | 244 (78.46%) | 159 (79.10%) | 85 (77.27%) | 0.85 |
| (−) | 67 (21.54%) | 42 (20.9%) | 25 (22.73%) | |
| Cerb2 (a) | ||||
| (+) | 83 (29.12%) | 57 (31.32%) | 26 (25.24%) | 0.44 |
| (−) | 202 (70.88%) | 125 (68.68%) | 77 (74.76%) | |
| NPI | 3.63 ± 1.89 | 3.53 ± 1.82 | 3.88 ± 1.95 | 0.17 |
| NPI | ||||
| < 2 | 49 (16.23%) | 30 (16.30%) | 19 (17.59%) | 0.04* |
| 2–2.4 | 55 (18.21%) | 29 (15.76%) | 16 (14.81%) | |
| 2.4–3.4 | 58 (19.21%) | 46 (25%) | 12 (11.11%) | |
| 3.4–5.4 | 53 (17.55%) | 30 (16.30%) | 23 (21.3%) | |
| > 5.4 | 87 (28.81%) | 49 (26.63%) | 38 (35.18%) | |
Data expressed as means ± standard deviation and absolute numbers and their frequencies.
NPI Nottingham prognostic index.
*p value < 0.05 (t-Student or Chi-squared).
aAnalysis performed on the cases provided by the pathology department.