Table 6.
Prognostic tumor characteristics in patients with breast cancer according to WHR (central obesity vs. no central obesity).
| Variable | All patients n = 304 (100%) |
WHR < 0.85 n = 121 (%) |
WHR ≥ 0.85 n = 183 (60.19%) |
p |
|---|---|---|---|---|
| Clinical tumor size (mm) | 23.22 ± 13.86 | 24.41 ± 18.72 | 21.64 ± 12.01 | 0.06 |
| Pathological tumor size (mm) | 22.95 ± 12.13 | 21.76 ± 15.24 | 23.48 ± 15.27 | 0.39 |
| Tumor size (cm) | ||||
| ≤ 2 cm | 137 (60.62%) | 54 (62.07%) | 83 (59.71%) | 0.11 |
| > 2 cm | 89 (39.38%) | 33 (37.93%) | 56 (40.29%) | |
| Clinical stage | ||||
| I | 106 (43.80%) | 44 (44.44%) | 62 (43.36%) | 0.24 |
| II, III | 118 (48.76%) | 46 (46.46%) | 72 (50.35%) | |
| III | 18 (7.44%) | 9 (9.09%) | 9 (6.29%) | |
| Pathological stage | ||||
| Initial (I) | 103 (39.77%) | 42 (42.42%) | 61 (38.13%) | 0.03 |
| Intermediate (II, III) | 136 (52.51%) | 47 (47.47%) | 89 (55.63%) | |
| Advanced (IV) | 20 (7.72%) | 10 (10.11%) | 10 (6.25%) | |
| Axillary involvement | ||||
| Negative | 154 (60.87%) | 58 (62.37%) | 96 (60%) | 0.00* |
| Positive | 99 (39.13%) | 35 (37.63%) | 64 (40%) | |
| Histological type | ||||
| Ductal | 263 (95.29%) | 109 (95.61%) | 154 (95.06%) | 0.64 |
| Lobulillar | 13 (4.71%) | 5 (4.39%) | 8 (4.94%) | |
| Differentiation degree | ||||
| 1, 2 | 172 (73.19%) | 68 (77.77%) | 104 (70.75%) | 0.00* |
| 3 | 63 (26.81%) | 20 (22.73%) | 43 (29.25%) | |
| Lymphovascular invasion (a) | ||||
| Yes | 13 (6.05%) | 5 (6.33%) | 8 (5.8%) | 0.02 |
| No | 202 (93.95%) | 74 (93.67%) | 128 (94.12%) | |
| Ki-67 (a) | ||||
| (+) | 32 (14.16%) | 16 (16.49%) | 16 (13.97%) | 0.13 |
| (−) | 201 (82.27%) | 81 (83.51%) | 120 (88.23%) | |
| Ki-67 (%) (a) | 25.45 ± 6.10 | 27.44 ± 12.23 | 24.90 ± 13.49 | 0.42 |
| ER | ||||
| (+) | 232 (84.98%) | 91 (83.49%) | 141 (85.98%) | 0.48 |
| (−) | 41 (15.02%) | 18 (16.51%) | 23 (14.02%) | |
| PR | ||||
| (+) | 214 (79.55%) | 85 (79.44%) | 129 (79.63%) | 0.29 |
| (−) | 55 (20.45%) | 22 (20.56%) | 33 (20.37%) | |
| Cerb2 (a) | ||||
| (+) | 69 (28.28%) | 22 (22.68%) | 47 (31.97%) | 0.23 |
| (−) | 175 (71.72%) | 75 (77.32%) | 100 (68.03%) | |
| NPI | 3.64 ± 1.83 | 3.21 ± 1.81 | 3.71 ± 1.84 | 0.04 |
| NPI | ||||
| < 2 | 43 (17.2%) | 18 (19.35%) | 25 (15.92%) | 0.00* |
| 2–2.4 | 44 (17.6%) | 19 (20.43%) | 25 (15.92%) | |
| 2.4–3.4 | 48 (19.2%) | 22 (23.66%) | 26 (16.56%) | |
| 3.4–5.4 | 47 (18.8%) | 14 (15.05%) | 33 (21.02%) | |
| > 5.4 | 68 (27.2%) | 20 (21.51%) | 48 (30.57%) | |
Data expressed as means ± standard deviation and absolute numbers and their frequencies.
NPI Nottingham prognostic index.
*p value < 0.05 (t-Student or Chi-squared).
aAnalysis performed on the cases provided by the pathology department.