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. 2021 Jan 21;12(1):105. doi: 10.1038/s41419-021-03411-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a Illustration of the HOXB4 domains. The relative position of the hexapeptide domain mediating cofactor (PBX) binding and the homeodomain mediating DNA binding were shown. b Oncomine analysis of HOXB4 expression in human cancers compared with normal tissues (www.oncomine.org). c–e Expression of HOXB4 in normal cervix and cervical cancer. Histopathology analysis (IHC staining) of HOXB4 was performed in 41 normal cervix (NC), 11 high-grade squamous intraepithelial lesion (HSIL), and 45 squamous cervical cancer (SCC). Representative images (c) with various levels of staining were shown. Scale bar: 10 μm. HOXB4 IHC staining was classified into two categories (negative or positive). Numbers of positive cases were shown (d). The relative IHC score (e) of HOXB4 was quantified as the product of the grade of staining intensity and the percentage of positively stained cells. One-way ANOVA was used to analyze the data. f Expression of HOXB4 in human tissues. Proteins were extracted from eight normal cervix tissues and eight SCC tumors and assessed by WB, with GAPDH normalization (f, left). The relative protein expression (f, right) of HOXB4 was normalized to that of GAPDH using ImageJ software. g HOXB4 mRNA expression levels in ten normal cervix tissues and fourteen SCC tumors and assessed by qRT-PCR. Data were normalized to GAPDH.