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. 2021 Jan 21;12(1):105. doi: 10.1038/s41419-021-03411-6

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a–i Inhibition of cell proliferation by HOXB4. Cell counting (a), MTT (b), and colony formation (c) assays were performed in HOXB4-overexpressing HeLa cells and control cells. Representative images of the colony formation assay with crystal violet staining (c, right) were shown, and colonies were quantified by counting (c, left). These proliferation experiments (cell counting, MTT, and colony formation assays) were also performed in HOXB4-overexpressing C-33A cells (d–f) and HOXB4-depleted SiHa cells (g–i). j–o Cell cycle distribution in modified transfected cervical cancer cell lines. Cell cycle profiles were obtained by FACS analysis of propidium iodide-stained cells and analyzed by flow cytometry in HOXB4-overexpressing HeLa (j, k) and C-33A (l, m) cells, as well as in HOXB4-depleted SiHa (n, o) cells.