Table 2.

Univariable Cox proportional hazards analysis of the risk of recurrence.

Patient characteristics	TCGA-HCC test cohort (n = 53)		Stanford-HCC (n = 198)
	Internal test set		External test set
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Risk score (binarized)	6.52 (1.83, 23.2)	0.0038	3.72 (2.17, 6.37)	< 0.0001
Age (at surgery)
> 60 years	0.83 (0.38, 1.8)	0.65	1.1 (0.64, 1.8)	0.77
Gender
Female	0.99 (0.44, 2.2)	0.98	0.99 (0.53, 1.9)	0.98
Hepatitis B virus infection
Positive	0.57 (0.22, 1.5)	0.25	1.1 (0.62, 1.9)	0.78
Hepatitis C virus infection
Positive	1.2 (0.4, 3.6)	0.74	0.66 (0.4, 1.1)	0.11
Alcohol intake
Positive	0.89 (0.37, 2.2)	0.80	0.19 (0.027, 1.4)	0.10
Non-alcoholic fatty liver disease
Positive	1.6 (0.46, 5.4)	0.48	1.8 (0.81, 3.9)	0.15
AJCC stage grouping
> II	1.3 (0.49, 3.6)	0.58	4.4 (2.3, 8.3)	< 0.0001
Largest tumor diameter (mm)
> 50	1.1 (0.52, 2.5)	0.74	3.5 (2.1, 5.8)	< 0.0001
Tumor multifocality
Positive	1.3 (0.53, 3.4)	0.53	1.1 (0.64, 1.9)	0.71
Histologic grade
> Moderately-differentiated	1.1 (0.44, 2.6)	0.90	2.1 (1.2, 3.9)	0.013
Microvascular invasion
Positive	1.4 (0.6, 3.1)	0.46	3.9 (2.4, 6.5)	< 0.0001
Macrovascular invasion
Positive	1.6 (0.46, 5.4)	0.48	5.3 (2.1, 1.3)	0.00043
Surgical margin
Positive	0.74 (0.22, 2.5)	0.63	6.8 (1.6, 28)	0.0090
Fibrosis stage
> 2	2.7 (0.98, 7.7)	0.054	0.33 (0.2, 0.55)	< 0.0001

CI, confidence interval.