Table 3.

Multivariable Cox proportional hazards analysis of the risk of recurrence.

Patient characteristics	TCGA-HCC test cohort (n = 53)		Stanford-HCC (n = 198)
	Internal test set		External test set
	Hazard ratio (95% CI)	p value	Hazard ratio (95% CI)	p value
Risk score (binarized)	7.44 (1.60, 34.6)	0.011	2.37 (1.27, 4.43)	0.00685
AJCC stage grouping
> II	0.30 (0.043, 2.11)	0.23	1.57 (0.63, 3.91)	0.331
Largest tumor diameter (mm)
> 50	1.09 (0.33, 3.60)	0.89	1.32 (0.67, 2.60)	0.425
Histologic grade
> Moderately-differentiated	2.82 (0.98, 8.1)	0.054	1.36 (0.69, 2.69)	0.377
Microvascular invasion
Positive	1.98 (0.59, 6.64)	0.27	2.84 (1.61, 5.00)	0.000294
Macrovascular invasion
Positive	3.76 (0.77, 18.4)	0.10	1.42 (0.42, 4.86)	0.575
Surgical margin
Positive	0.51 (0.079, 3.3)	0.47	4.45 (0.84, 23.7)	0.0797
Fibrosis stage
> 2	0.80 (0.20, 3.1)	0.74	0.50 (0.28, 0.90)	0.0217

CI, confidence interval.