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. 2021 Jan 21;11:2037. doi: 10.1038/s41598-021-81570-4

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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SERCA2a ameliorated contractility /calcium transient of cardiomyocytes and cardiac function in vivo via calpain/JPH2/T-tubule in myocardial I/R mice. (A) Representative contractility tracings in each group. n = 11 to 22 cells from 3–5 hearts per group; mean ± SEM. (B) Summary data of contractility in each group. (C) Representative Ca²⁺ transient tracings in each group. n = 11 to 22 cells from 3–5 hearts per group ; mean ± SEM. (D) Summary data of Ca²⁺ transient amplitudes in each group. (E) Representative M-mode transthoracic views in each group. n = 4–6; mean ± SEM. (F, G) Summary data of cardiac function (EF, FS). Individual data points are presented in Supplemental Fig. 5B/D/E. *P < 0.05, **P < 0.01, ***P < 0.001 versus sham; ^#P < 0.05, ^##P < 0.01, ^###P < 0.001 versus I/R; ^&P < 0.05, ^&&P < 0.01, ^&&&P < 0.001 versus PD + I/R; ^$$$P < 0.001 versus SERCA2a KO; ^{^}P < 0.05, ^{^^^}P < 0.001 versus SERCA2a KO + I/R; ^@P < 0.05, ^@@P < 0.01, ^@@@P < 0.001 versus Ad-GFP + I/R.