Table 2.
Effect of topical application of hydroalcoholic extracts of experimental medicinal plants on percent wound contraction and epithelization time of an excision wound in mice.
| Groups | Wound area (mm2) ± SEM (% Contraction) |
EP (in days) | ||||||
|---|---|---|---|---|---|---|---|---|
| 2 | 4 | 6 | 8 | 10 | 12 | 14 | ||
| SO (control) | 227.81 ± 14.19 (27.45) | 177.88 ± 15.27 (43.35) | 146.05 ± 21.96 (53.49) | 103.35 ± 17.71 (67.09) | 64.61 ± 15.64 (79.43) | 42.39 ± 8.03 (86.50) | 31.72 ± 9.24 (89.90) | 17.80 ± 1.07 |
| 5% w/w DA | 145.62 ± 26.70 (53.63) | 116.38 ± 24.53 (62.94) | 73.83 ± 14.75∗1 (76.49) | 48.87 ± 10.20∗2 (84.44) | 21.00 ± 6.36∗2 (93.31) | 7.07 ± 2.51∗3 (97.75) | 2.67 ± 1.30∗3 (99.15) | 14.00 ± 0.63∗2 |
| 10% w/w DA | 140.91 ± 24.07 (55.13) | 111.83 ± 22.41 (64.39) | 70.69 ± 9.99∗1 (77.49) | 41.45 ± 5.88∗2 (86.80) | 16.02 ± 3.65∗2 (94.90) | 3.46 ± 1.58∗3 (98.90) | 0.32 ± 0.19∗3 (99.90) | 13.60 ± 0.68∗2 |
| 5% w/w RP | 148.88 ± 15.39 (52.59) | 113.55 ± 15.68 (63.84) | 85.76 ± 14.72 (72.69) | 59.19 ± 8.17 (81.15) | 36.74 ± 4.07 (88.30) | 18.21 ± 1.41∗2 (94.20) | 5.65 ± 0.38∗3 (98.20) | 15.20 ± 0.37 |
| 10% w/w RP | 137.57 ± 18.07∗1 (56.19) | 97.11 ± 13.96∗1 (69.08) | 68.93 ± 9.29∗1 (78.05) | 42.90 ± 6.75∗2 (86.34) | 26.61 ± 7.28∗2 (91.53) | 13.50 ± 4.90∗3 (95.70) | 3.14 ± 1.43∗3 (99.00) | 14.20 ± 0.74∗1 |
| 5% w/w BA | 153.75 ± 18.98 (51.04) | 116.14 ± 11.42 (63.01) | 106.81 ± 23.94 (65.98) | 59.19 ± 8.17 (81.15) | 37.72 ± 3.66 (87.99) | 21.67 ± 2.98∗1 (93.10) | 7.22 ± 0.46∗3 (97.70) | 15.80 ± 0.20 |
| 10% w/w BA | 138.83 ± 23.03 (55.79) | 103.43 ± 18.29 (67.06) | 72.26 ± 9.92∗1 (76.99) | 42.90 ± 6.75∗2 (86.34) | 26.14 ± 6.36∗2 (91.68) | 14.13 ± 4.49∗3 (95.50) | 4.16 ± 1.98∗3 (98.68) | 14.40 ± 0.68∗1 |
| 0.2%NF | 127.68 ± 11.57∗1 (59.34) | 91.26 ± 11.30∗1 (70.94) | 68.14 ± 10.53∗1 (78.30) | 43.69 ± 8.44∗3 (86.09) | 10.99 ± 4.76∗3 (96.50) | 3.14 ± 2.43∗3 (99.00) | 0.00 ± 0∗3 (100.00) | 12 ± 0.707∗3,+2,@1 |
Values are expressed as mean ± SEM (n = 6 animals in each group) and analyzed by one-way ANOVA followed by tuckey post hoc test; numbers from 2-14 indicate the day on which contraction rate measurement was taken; EP = epithelization period; SO = simple ointment (control) base; DA = Dodonaea angustifolia; RP = Rhamnus prinoides; BA = Brucea antidysentrica, NF = nitrofurazone ointment, ∗: compared against the control, + = against 5% Brucea antidysentrica, @ = against 5%Rhamnus prinoides, 1p < 0.05; 2p < 0.01; 3p < 0.001.