Table 3.
Effect of topical application of 80 % hydroalcoholic extracts of the of leaves of Dodonaea angustifolia, Rhamnus prinoides and root barks of Brucea antidysentrica on breaking strength of an incision wound model on day 10 of wound creation.
| Dose | Breaking strength (g) | % Tensile strength |
|---|---|---|
| LU | 131.04 ± 2.25 | - |
| SO (control) | 161.0 ± 9.2 | 12.86 |
| 5% w/w DA | 262.5 ± 34.4∗2+3 | 63.04 |
| 10% w/w DA | 288.5 ± 19.8∗2+3 | 79.19 |
| 5% w/w RP | 241.9 ± 10.9+3 | 50.25 |
| 10% w/w RP | 252.1 ± 18.6∗1+3 | 56.58 |
| 5% w/w BA | 234.3 ± 9.9+3 | 45.52 |
| 10% w/w BA | 248.1 ± 18.6∗1 +3 | 54.10 |
| 0.2%NF | 310.6 ± 4.924∗3+3 | 92.92 |
Values are expressed as mean ± SEM (n = 6 animals in each group) and analyzed by one-way ANOVA followed by Tuckey post hoc test; tensile strength was measured on the 10th post-wounding day using continuous water flow technique; SO = simple ointment base; LU = left untreated control; DA = Dodonaea angustifolia; RP = Rhamnus prinoides; BA = Brucea antidysentrica, NF = nitrofurazone ointment, ∗: compared against the control, +: compared against left untreated 1p < 0.05; 2p < 0.01; 3p < 0.001.