Table 1.
Laboratory and enzyme-linked immunosorbent assay results obtained at 240 min.
| Sham | Control-IR | Dex-Sham | Dex-IR | IR-Dex | P value | |
|---|---|---|---|---|---|---|
| AST (U/L) | 73 (11) | 159 (32) | 77 (11) | 182 (34) | 152 (26) | < 0.01 |
| ALT (U/L) | 26 (4) | 30 (8) | 24 (5) | 27 (3) | 27 (8) | 0.45 |
| Creatinine (mg/dL) | 0.1 (0.1–0.1) | 0.4 (0.3–0.4) | 0.3 (0.2–0.3) | 0.4 (0.4–0.5) | 0.4 (0.4–0.4) | 0.06 |
| NGAL (ng/mL) | 2077 (1129) | 3216 (1442) | 2047 (1281) | 3132 (1867) | 2043 (1319) | 0.13 |
| MCP-1 (pg/mL) | 508 (166) | 668 (359) | 802 (412) | 999 (933) | 634 (400) | 0.29 |
| KIM (pg/mL) | 825 (163) | 886 (191) | 871 (140) | 954 (256) | 1007 (328) | 0.41 |
| Lactate (mmol/L) | 0.9 (0.2) | 1.0 (0.3) | 1.0 (0.3) | 0.9 (0.2) | 0.8 (0.2) | 0.28 |
Data are presented as mean (SD), except for creatinine which is presented as median (interquartile range); n = 10 for each group. AST was found to be statistically significant based on an one-way analysis of variance, but further post hoc analysis using Tukey’s test showed that AST did not differ significantly among the Dex‒Sham, Dex‒IR, IR‒Dex and Control‒IR groups. Sham indicates sham operation; Control‒IR, left kidney ischemia for 60 min and reperfusion; Dex‒Sham, sham operation and infusion of dexmedetomidine; Dex‒IR, pre-ischemia infusion of dexmedetomidine 30 min before left kidney ischemia; IR‒Dex, post-ischemia infusion of dexmedetomidine 30 min after reperfusion of the left ischemic kidney; AST, aspartate aminotransferase; ALT, alanine aminotransferase; MCP-1, monocyte chemoattractant protein-1; NGAL, neutrophil gelatinase-associated lipocalin; KIM-1, kidney injury molecule-1.