Table 5.
Demographic and clinicopathological features of the individuals with or without Parkinson’s disease diagnosis.
| Cases | DxAP | Sex | Age (years) | PMD (hh:mm) | Brain weight (g) | Stage | Disease duration (years) | Original fixation | Cause of death | Iba-1 | Neu-N | Cavalieri | GFAP | α-Syn |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | PD | M | 73 | 1:00 | 1450 | Braak 6 | 1,5 | Fd | Cardiorespiratory arrest | X | X | X | X | |
| 2 | PD | F | 82 | 2:00 | 1300 | Braak 5 | 22 | Fd | Cardiorespiratory arrest (immediate), intestinal ischemia (secondary) | X | X | X | X | |
| 3 | PD | M | 82 | 5:00 | m.d. | Braak 6 | 8 | Fd | m.d. | X | X | X | X | |
| 4 | PD | M | 65 | m.d. | 1305 | Braak 6 | 9 | Fd | m.d. | X | X | X | X | |
| 5 | PD | M | 80 | m.d. | 1231 | Braak 5 | m.d. | Fd | m.d. | X | X | X | X | X |
| 6 | PD | F | 87 | 2:00 | 1100 | Braak 6 | 10 | Fr | Cardiorespiratory arrest | X | X | X | ||
| 7 | PD | F | 81 | 12:20 | 1105 | Braak 6 | 13 | Fr | Urinary sepsis | X | X | X | X | X |
| 8 | PD | F | 84 | 4:30 | 1050 | Braak 4 | 22 | Fr | Acute myocardial infarction | X | X | X | X | X |
| 9 | PD | F | 81 | 6:30 | 1010 | Braak 4 | 12 | Fr | Hepatic carcinoma | X | X | X | X | X |
| 10 | PD | M | 85 | 12:15 | 1355 | Braak 5 | 12 | Fr | Bronchoaspiration | X | X | X | X | |
| 11 | PD | F | 87 | 7:00 | 1140 | Braak 6 | 20 | Fr | Bronchoaspiration | X | X | X | X | X |
| 12 | PD | M | 74 | 8:00 | 1305 | Braak 5 | 19 | Fr | Pneumonia | X | X | X | ||
| 13 | PD | M | 87 | 15:15 | m.d. | Braak 5 | m.d. | Fr | m.d. | X | X | X | X | |
| 14 | PD | M | 78 | 5:15 | 1210 | Braak 5 | m.d. | Fr | Bronchoaspiration | X | X | X | X | X |
| 15 | PD | F | 75 | 3:45 | m.d. | Braak 5 | m.d. | Fr | m.d. | X | X | X | X | X |
| 16 | PD | M | 72 | 6:00 | 1160 | Braak 6 | 15 | Fr | Advanced cognitive impairment + renal insufficiency | X | X | X | X | X |
| 17 | PD | M | 62 | 13:30 | 1355 | Braak 5 | 12 | Fr | Cardiorespiratory arrest | X | ||||
| 18 | NPD | F | 62 | 2:00 | 1050 | – | – | Fr | Cardiorespiratory arrest (immediate), Multiple organ dysfunction syndrome (secondary) | X | X | X | X | |
| 19 | NPD | M | 58 | 6:00 | 1500 | – | – | Fr | Acute myocardial infarction (immediate), ischemic heart disease (secondary) | X | X | X | X | |
| 20 | NPD | F | 59 | 2:00 | 1200 | – | – | Fr | Severe acute pancreatitis (immediate), Cardiorespiratory arrest (secondary) | X | X | X | X | |
| 21 | NPD | M | 53 | 5:00 | 1300 | – | – | Fr | Cardiorespiratory arrest (immediate), rectal carcinoma (secondary) | X | X | X | X | |
| 22 | NPD | M | 78 | 4:00 | 1100 | – | – | Fr | Respiratory insufficiency (immediate), lung cancer (secondary) | X | X | X | X | |
| 23 | NPD | F | 81 | 5:00 | 1100 | – | – | Fd | Multiple organ dysfunction syndrome | X | X | X | X | |
| 24 | NPD | M | 75 | 4:00 | 1250 | – | – | Fd | Multiple organ dysfunction syndrome | X | X | X | X | |
| 25 | NPD | F | 58 | 944 | – | – | Fd | X | X | X | X | |||
| 26 | NPD | M | 80 | 10:00 | 1310 | – | – | Fr | Piriformis sinus carcinoma | X | X | X | X | |
| 27 | NPD | M | 69 | 10:15 | 1110 | – | – | Fr | Pneumonia | X | X | X | ||
| 28 | NPD | M | 73 | 6:10 | 1030 | – | – | Fr | Bronchoaspiration | X | X | X |
DxAP neuropathological diagnosis, PMD post-mortem duration, PD Parkinson’s disease, NPD non-Parkinson’s disease, M male, F female, m.d. missing data, Fd formaldehyde, Fr frozen no-fix.