Figure 5.
Takayasu arteritis genetic susceptibility loci identified and the main Gene Ontology terms represented
(A) Schematic illustration depicting the susceptibility loci identified in this study. Loci surpassing the genome-wide level of significance (p value < 5 × 10−8) are highlighted in red.
(B) Gene Ontology (GO) enrichment analysis. Biological Process GO clusters revealed with genes annotated to genetic susceptibility loci identified in this study (p value < 5 × 10−5). Only clusters detected with a p value < 1 × 10−3 and that included at least three genes are shown. Each node corresponds with a GO term, and edges represent connections between GO terms. Each GO cluster is defined by a different color and the most-associated Biological Process within each cluster is highlighted.