Table 1.
Stepwise conditional analysis of the HLA variants and the imputed classical HLA alleles to detect independent associations with Takayasu arteritis
| Covariates | Risk factor | p value | OR | Position (HG19) | Locus |
|---|---|---|---|---|---|
| SNPs | |||||
| none | rs2844678 | 5.70E−47 | 2.71 | 30950050 | 5′ MUC21 |
| rs2844678 | rs12524487 | 5.72E−38 | 3.12 | 31354238 | HLA-B/MICA |
| rs2844678 + rs12524487 | rs17193507 | 7.08E−30 | 3.28 | 31351054 | HLA-B/MICA |
| rs2844678 + rs12524487 + rs17193507 | rs12526858 | 1.55E−10 | 2.70 | 31323721 | HLA-B |
| rs2844678 + rs12524487 + rs17193507 + rs12526858 | rs28749167 | 1.90E−9 | 1.43 | 29921034 | HLA-G |
| Classical alleles | |||||
| none | HLA-B∗5201 | 4.16E−36 | 4.37 | N/A | N/A |
| HLA-B∗5201 | HLA-B∗1302 | 2.96E−25 | 3.21 | N/A | N/A |
| HLA-B∗5201 + HLA-B∗1302 | HLA-B∗1501 | 1.09E−15 | 3.07 | N/A | N/A |
| HLA-B∗5201 + HLA-B∗1302 + HLA-B∗1501 | HLA-DQB1∗0502 | 3.88E−8 | 1.90 | N/A | N/A |
Abbreviations are as follows: SNP, single nucleotide polymorphism; OR, odds ratio.