Table 2.
Meta-analysis results showing the most significant genetic variant in each locus associated with Takayasu arteritis at a genome-wide level of significance (p value < 5E−8)
| Locus | Chr | Position (HG19) | SNP | Location | Minor allele | p value | OR | Q statistic p value |
|---|---|---|---|---|---|---|---|---|
| VPS8a | 3 | 184612321 | rs58693904 | intronic | T | 3.73E−9 | 1.51 | 0.550 |
| IL12B | 5 | 158804928 | rs4379175 | upstream | T | 3.13E−9 | 1.36 | 0.173 |
| PTK2B | 8 | 27195121 | rs28834970 | intronic | C | 1.40E−9 | 0.71 | 0.957 |
| SVEP1a | 9 | 113117183 | rs7038415 | upstream | A | 4.90E−8 | 1.45 | 0.174 |
| chr13q21a | 13 | 65078467 | rs9540128 | intergenic | T | 1.89E−8 | 2.02 | 0.793 |
| CFL2a | 14 | 35189914 | rs76457959 | upstream | T | 2.84E−9 | 1.62 | 0.682 |
| chr21q22 | 21 | 40464924 | rs4817983 | intergenic | C | 1.92E−12 | 0.64 | 0.125 |
Abbreviations are as follows: Chr, chromosome; SNP, single nucleotide polymorphism; OR, odds ratio.
a
Novel previously unreported genetic loci in Takayasu arteritis.