Table 1.
Baseline characteristics at diagnosis
| Characteristic | Total (n = 90) |
|---|---|
| Sex, male/female (n = 90) | 53 (58.9)/37 (41.1) |
| Age, yr (n = 950) | 61.5 (25–93) |
| Hypertension (n = 89) | 22 (24.4) |
| Diabetes mellitus (n = 89) | 11 (12.2) |
| History of cancer (n = 90) | 4 (4.4) |
| Comorbidity (n = 89)a | 16 (17.8) |
| Constitutional symptom (n = 89) | 14 (15.6) |
| Lymphadenopathy (n = 84) | 45 (50.0) |
| Bulky lymph node (> 5 cm) (n = 90) | 2 (2.2) |
| Hepatomegaly (n = 82) | 4 (4.4) |
| Splenomegaly (n = 83) | 28 (31.1) |
| Extranodal involvement (n = 90) | 4 (4.4) |
| WBC count, × 103/μL (n = 90) | 27.4 (3.83–447.4) |
| Hemoglobin, g/dL (n = 90) | 12.6 (2.1–19.9) |
| Platelet, × 103/μL (n = 90) | 175.5 (5–308) |
| Lymphocyte count, × 103/μL (n = 88) | 22.8 (1.4–438.5) |
| Bone marrow cellularity, % (n = 68) | 60 (10–100) |
| Bone marrow neoplastic cells, % (n = 63) | 77.0 (9.0–96.1) |
| LDH (n = 73) | 285 (112–1112) |
| Stage (Binet system) (n = 90) | |
| A | 54 (60.0) |
| B | 9 (10.0) |
| C | 27 (30.0) |
| Cytogenetics (n = 73)b | |
| Normal karyotype | 60 (66.7) |
| Inv(9)/dup(9) | 3 (3.3) |
| Del(13q) | 1 (1.1) |
| Del(11q) | 2 (2.2) |
| Trisomy 12 | 2 (2.2) |
| Complex karyotype (≥ 3) | 3 (3.3) |
| Others | 2 (2.2) |
| FISH | |
| IgH gene rearrangement (n = 20) | 6 |
| Del(13q) (n = 18) | 7 |
| Trisomy 12 (n = 21) | 6 |
| Del(11q) (n = 20) | 2 |
| Del(17p) (n = 25) | 2 |
Values are presented as number (%) or median (range).
WBC, white blood cell; LDH, lactate dehydrogenase; FISH, f luorescence in situ hybridization; IgH, immunoglobulin heavy locus.
a
Comorbidity includes cerebrovascular disease, heart disease, liver disease, and lung disease other than hypertension, diabetes and prior cancers.
b
At the time of diagnosis.