Table 5.
Multivariate analysis
| Variable | Overall survival |
Progression-free survival |
||
|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | |
| WBC count, ≥ 100, × 103/μLa | 4.748 (1.084–20.792) | 0.039 | - | - |
| Extranodal involvementa | 21.639 (2.972–157.553) | 0.002 | - | |
| Binet systema | ||||
| A | Reference | - | ||
| B | 0.455 (0.040–5.108) | 0.523 | - | |
| C | 4.354 (1.117–16.975) | 0.034 | - | |
| Cytogeneticsa | ||||
| Normal karyotype/other chromosomes | Reference | Reference | ||
| Del(11q) or del(17) or CK | 17.022 (3.674–78.864) | < 0.001 | 9.620 (1.732–53.444) | 0.010 |
| IgH mutation | - | 0.988 | 0.503 (0.114–2.215) | 0.364 |
HR, hazard ratio; CI, confidence interval; WBC, white blood cell; CK, complex karyotype (≥ 3); IgH, immunoglobulin heavy locus.
a
At the time of diagnosis.