Table 6.

European LeukaemiaNet criteria for hydroxyurea intolerance and resistance in patients with essential thrombocythemia

1. Platelet count > 600 × 109/L after 3 months of at least 2 g/day of hydroxyurea (2.5 g/day in patients with a body weight > 80 kg), OR

2. Platelet count > 400 × 109/L and WBC count < 2.5 × 109/L at any dose of hydroxyurea, OR

3. Platelet count > 400 × 109/L and hemoglobin < 10 g/dL at any dose of hydroxyurea, OR

4. Presence of leg ulcers or other unacceptable mucocutaneous manifestations at any dose of hydroxyurea, OR

5. Hydroxyurea-related fever